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Each time my wife's friend comes over to visit I stare at her boobs. Once I asked the if she would give me a blowjob since Sally won't sick my dick. Now we have casual sex often

The only well-documented cases of antibiotics interfering with hormonal contraceptives that I'm aware of is the antibiotic drug Rifampicin. So yes, it is possible (if unlikely, since Rifampicin isn't used much). However, the advice to ask a doctor is always good advice, even to hypotheticals because if you're ever in that position, we don't want you relying on us, random Internet people, over asking your doctor (or better yet, pharmacist with up-to-date access to journals and drug manuals.